Designer Opioids (2018 Scope), Blood

Method(s)

High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)

Suggested CPT Code(s)

80354

80364

New York State Approval Status

Approved

Known Interference(s)

Cyclopropylfentanyl [LC-MS/MS]: Crotonyl fentanyl impurity

Isobutyrylfentanyl [LC-MS/MS]: beta-methylfentanyl

ortho-Fluorofentanyl [LC-MS/MS]: Ortho-fluorobutyrylfentanyl impurity

para-Fluorobutyrylfentanyl [LC-MS/MS]: meta-Fluorobutyrylfentanyl

para-Fluorofentanyl [LC-MS/MS]: Meta-fluorofentanyl

trans-3-Methylfentanyl [LC-MS/MS]: Crotonyl fentanyl

Turnaround Time

4 days

Test Includes


1	Methoxyacetylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
2	4-ANPP	Despropionyl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.1	NPS
3	THF-F	Tetrahydrofuran fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
4	meta-Methylmethoxyacetylfentanyl	3-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
5	para-Methylmethoxyacetylfentanyl	4-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
6	Acryl Fentanyl	Acryloylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
7	para-Fluorofentanyl	4-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Meta-fluorofentanyl
8	ortho-Fluorofentanyl	2-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Ortho-fluorobutyrylfentanyl impurity
9	2-Furanylfentanyl	Fu-F; Furanylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
10	U-47700	U-4	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
11	U-49900		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
12	U-51754		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
13	Carfentanil	Carfentanyl; Wildnil®	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
14	Cyclopropylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonyl fentanyl impurity
15	trans-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonyl fentanyl
16	cis-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
17	Isobutyrylfentanyl	Isobutyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	beta-methylfentanyl
18	Butyrylfentanyl	Butyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
19	para-Fluoroisobutyrylfentanyl	4F-Isobutyrylfentanyl; FIBF	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
20	para-Fluorobutyrylfentanyl	4F-butyryl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	meta-Fluorobutyrylfentanyl
21	Valeryl Fentanyl	Pentylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS

Compliance Statement

This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the US Food and Drug Administration.

Sample Type

Blood

Requested Volume

Minimum Volume

0.7 mL

Special Handling

None

Sample Container

Gray top tube (Sodium Fluoride / Potassium Oxalate)

Additional Collection Instructions

Transport Temperature

Frozen

Light Protection

Not Required

Rejection Criteria

Received Room Temperature. Received Refrigerated.

Rejection criteria pertain to clinical sample submissions only.

Stability

Room Temperature: Not Stable
Refrigerated: 2 day(s)
Frozen (-20 °C): 14 day(s)


1	Methoxyacetylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
2	4-ANPP	Despropionyl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.1	NPS
3	THF-F	Tetrahydrofuran fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
4	meta-Methylmethoxyacetylfentanyl	3-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
5	para-Methylmethoxyacetylfentanyl	4-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
6	Acryl Fentanyl	Acryloylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
7	para-Fluorofentanyl	4-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Meta-fluorofentanyl
8	ortho-Fluorofentanyl	2-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Ortho-fluorobutyrylfentanyl impurity
9	2-Furanylfentanyl	Fu-F; Furanylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
10	U-47700	U-4	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
11	U-49900		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
12	U-51754		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
13	Carfentanil	Carfentanyl; Wildnil®	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
14	Cyclopropylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonyl fentanyl impurity
15	trans-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonyl fentanyl
16	cis-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
17	Isobutyrylfentanyl	Isobutyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	beta-methylfentanyl
18	Butyrylfentanyl	Butyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
19	para-Fluoroisobutyrylfentanyl	4F-Isobutyrylfentanyl; FIBF	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
20	para-Fluorobutyrylfentanyl	4F-butyryl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	meta-Fluorobutyrylfentanyl
21	Valeryl Fentanyl	Pentylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS

Example Report (Negative)

Example Report (Positive)

Interface Map

1480B Designer Opioids (2018 Scope), Blood - Current Version
Analyte	Units	Analyte Mapping Code
Methoxyacetylfentanyl	ng/mL	MXYACFEN
4-ANPP	ng/mL	4ANPP
THF-F	ng/mL	THFF
meta-Methylmethoxyacetylfentanyl	ng/mL	MMMAFENT
para-Methylmethoxyacetylfentanyl	ng/mL	PMMAFENT
Acryl Fentanyl	ng/mL	ACRYLFEN
para-Fluorofentanyl	ng/mL	PFLFENT
ortho-Fluorofentanyl	ng/mL	OFLFENT
2-Furanylfentanyl	ng/mL	2FURANF
U-47700	ng/mL	U47700
U-49900	ng/mL	U49900
U-51754	ng/mL	U51754
Carfentanil	ng/mL	CARFENTANI
Cyclopropylfentanyl	ng/mL	CYCLOFEN
trans-3-Methylfentanyl	ng/mL	3TRANMFENT
cis-3-Methylfentanyl	ng/mL	3CISMFENT
Isobutyrylfentanyl	ng/mL	IBUTYRF
Butyrylfentanyl	ng/mL	BUTYRFEN
para-Fluoroisobutyrylfentanyl	ng/mL	FIBF1
para-Fluorobutyrylfentanyl	ng/mL	PFBF
Valeryl Fentanyl	ng/mL	VALFENT

1480B Designer Opioids (2018 Scope), Blood - **Effective 04/04/2022**
Analyte	Units	Analyte Mapping Code
Methoxyacetylfentanyl	ng/mL	MXYACFEN
4-ANPP	ng/mL	4ANPP
THF-F	ng/mL	THFF
meta-Methylmethoxyacetylfentanyl	ng/mL	MMMAFENT
para-Methylmethoxyacetylfentanyl	ng/mL	PMMAFENT
Acryl Fentanyl	ng/mL	ACRYLFEN
para-Fluorofentanyl	ng/mL	PFLFENT
ortho-Fluorofentanyl	ng/mL	OFLFENT
2-Furanylfentanyl	ng/mL	2FURANF
U-47700	ng/mL	U47700
U-49900	ng/mL	U49900
U-51754	ng/mL	U51754
Carfentanil	ng/mL	CARFENTANI
Cyclopropylfentanyl	ng/mL	CYCLOFEN
trans-3-Methylfentanyl	ng/mL	3TRANMFENT
cis-3-Methylfentanyl	ng/mL	3CISMFENT
Isobutyrylfentanyl	ng/mL	IBUTYRF
Butyrylfentanyl	ng/mL	BUTYRFEN
para-Fluoroisobutyrylfentanyl	ng/mL	FIBF1
para-Fluorobutyrylfentanyl	ng/mL	PFBF
Valeryl Fentanyl	ng/mL	VALFENT

LOINC^® Information

1480B Designer Opioids (2018 Scope), Blood - Current Version
Analyte	Units	Analyte Mapping Code
Methoxyacetylfentanyl	ng/mL	MXYACFEN
4-ANPP	ng/mL	4ANPP
THF-F	ng/mL	THFF
meta-Methylmethoxyacetylfentanyl	ng/mL	MMMAFENT
para-Methylmethoxyacetylfentanyl	ng/mL	PMMAFENT
Acryl Fentanyl	ng/mL	ACRYLFEN
para-Fluorofentanyl	ng/mL	PFLFENT
ortho-Fluorofentanyl	ng/mL	OFLFENT
2-Furanylfentanyl	ng/mL	2FURANF
U-47700	ng/mL	U47700
U-49900	ng/mL	U49900
U-51754	ng/mL	U51754
Carfentanil	ng/mL	CARFENTANI
Cyclopropylfentanyl	ng/mL	CYCLOFEN
trans-3-Methylfentanyl	ng/mL	3TRANMFENT
cis-3-Methylfentanyl	ng/mL	3CISMFENT
Isobutyrylfentanyl	ng/mL	IBUTYRF
Butyrylfentanyl	ng/mL	BUTYRFEN
para-Fluoroisobutyrylfentanyl	ng/mL	FIBF1
para-Fluorobutyrylfentanyl	ng/mL	PFBF
Valeryl Fentanyl	ng/mL	VALFENT

1480B Designer Opioids (2018 Scope), Blood - **Effective 04/04/2022**
Analyte	Units	Analyte Mapping Code
Methoxyacetylfentanyl	ng/mL	MXYACFEN
4-ANPP	ng/mL	4ANPP
THF-F	ng/mL	THFF
meta-Methylmethoxyacetylfentanyl	ng/mL	MMMAFENT
para-Methylmethoxyacetylfentanyl	ng/mL	PMMAFENT
Acryl Fentanyl	ng/mL	ACRYLFEN
para-Fluorofentanyl	ng/mL	PFLFENT
ortho-Fluorofentanyl	ng/mL	OFLFENT
2-Furanylfentanyl	ng/mL	2FURANF
U-47700	ng/mL	U47700
U-49900	ng/mL	U49900
U-51754	ng/mL	U51754
Carfentanil	ng/mL	CARFENTANI
Cyclopropylfentanyl	ng/mL	CYCLOFEN
trans-3-Methylfentanyl	ng/mL	3TRANMFENT
cis-3-Methylfentanyl	ng/mL	3CISMFENT
Isobutyrylfentanyl	ng/mL	IBUTYRF
Butyrylfentanyl	ng/mL	BUTYRFEN
para-Fluoroisobutyrylfentanyl	ng/mL	FIBF1
para-Fluorobutyrylfentanyl	ng/mL	PFBF
Valeryl Fentanyl	ng/mL	VALFENT

Some LOINC^® codes may not have been assigned or are not available.

This material contains content from LOINC (http://loinc.org). LOINC is copyright ^® 1995-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license. LOINC^® is a registered United States trademark of Regenstrief Institute, Inc.

The CPT Codes provided in this document are based on AMA Guidelines and are for informational purposes only. NMS Labs Does not assume responsibility for billing errors due to Reliance on the CPT Codes listed in this document.

*The information contained in this document represents database configurations, as they will appear on the effective date listed above.